Neuropsychological profiles of patients suffering from hallucinogen persisting perception disorder (HPPD): A comparative analysis with psychedelic-using and non-using controls
2024

Neuropsychological Profiles of Patients with HPPD

Sample size: 8 publication 10 minutes Evidence: moderate

Author Information

Author(s): Georg Leistenschneider, Tomislav Majić, Simon Reiche, Thomas G. Riemer

Primary Institution: Humboldt-Universität zu Berlin

Hypothesis

What are the neuropsychological profiles of patients suffering from Hallucinogen Persisting Perception Disorder (HPPD) compared to psychedelic-using and non-using controls?

Conclusion

The study found that individuals with HPPD exhibited below average results in tests of visual memory and executive function, indicating potential cognitive impairments.

Supporting Evidence

  • Patients with HPPD showed below average performance in visual memory tests.
  • Four out of eight HPPD patients had impaired executive functions.
  • The study highlights the need for further research into the cognitive effects of HPPD.

Takeaway

People with HPPD may have trouble remembering things and making decisions, which can make everyday life harder for them.

Methodology

The study used a comprehensive neuropsychological test battery to assess cognitive performance in HPPD patients and compared results with two control groups.

Potential Biases

Potential selection bias due to the recruitment of participants with specific experiences.

Limitations

The small sample size and the exploratory nature of the study limit the ability to draw definitive conclusions.

Participant Demographics

The HPPD group consisted of eight participants, including one female, with a mean age of 27.6 years.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1038/s41598-024-82216-x

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