How UP States Protect Cortical Activity from Thalamic Inputs
Author Information
Author(s): Brendon O. Watson, Jason N. MacLean, Rafael Yuste, Dietmar Plenz
Primary Institution: Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York, United States of America
Hypothesis
Do UP states protect ongoing cortical activity from thalamic inputs?
Conclusion
Cortical dynamics during UP states are insensitive to thalamic inputs.
Supporting Evidence
- Thalamic stimulation during DOWN states generated synchronized UP states.
- Thalamic stimulation during UP states had no effect on neuronal dynamics.
- Input resistance was significantly decreased during cortical UP states.
Takeaway
When the brain is in a special state called an UP state, it doesn't react to signals from the thalamus, which usually helps process information.
Methodology
Calcium imaging and targeted whole-cell recordings were used in thalamocortical slices of mouse somatosensory cortex.
Limitations
The study was conducted in vitro, which may not fully replicate in vivo conditions.
Participant Demographics
P13-18 mice were used for the experiments.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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