Adiponectin Gene Polymorphism and Its Link to Metabolic Syndrome and Hypertension
Author Information
Author(s): Leu Hsin-Bang, Chung Chia-Min, Lin Shing-Jong, Jong Yuh-Shiun, Pan Wen-Harn, Chen Jaw-Wen, Kronenberg Florian
Primary Institution: National Yang-Ming University, Taipei, Taiwan, R.O.C.
Hypothesis
This study aimed to investigate the association of the ADIPOQ gene with the phenotypes of hypertension and metabolic syndrome.
Conclusion
ADIPOQ genetic variants were selectively and specifically associated with the concomitant presence of metabolic syndrome and hypertension.
Supporting Evidence
- The lowest plasma adiponectin value was observed in metabolic syndrome with hypertension component compared to hypertensives or metabolic syndrome without hypertension.
- The SNP rs1501299 (G276T) in the ADIPOQ gene was found associated with the presence of hypertension in metabolic syndrome.
- The significant association of the SNP rs1501299 with the phenotype of presence of hypertension in metabolic syndrome was confirmed in the replication study.
Takeaway
The study found that certain genetic variations in the adiponectin gene are linked to having both metabolic syndrome and high blood pressure, which could help understand their connection.
Methodology
A family-based association study with 962 participants and a replication study with 1448 unrelated participants were conducted to analyze the association of ADIPOQ gene variants with hypertension and metabolic syndrome.
Limitations
The study had unequal case numbers in different phenotypes, which may affect statistical power, and the selected SNP markers may not fully capture the genetic connection to plasma adiponectin levels.
Participant Demographics
495 men and 467 women from 302 nuclear families.
Statistical Information
P-Value
p=0.02
Confidence Interval
95% CI: 1.14-5.3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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