3D Cardiac Metabolism Imaging with Hyperpolarized Pyruvate
Author Information
Author(s): Frijia Francesca, Wiesinger Florian, Santarelli Maria Filomena, Positano Vincenzo, Ardenkjaer-Larsen Jan Henrik, Schulte Rolf, Menichetti Luca, Giovannetti Giulio, Bianchi Giacomo, Aquaro Giovanni, Lionetti Vincenzo, De Marchi Daniele, Flori Alessandra, Landini Luigi, Recchia Fabio Anastasio, Lombardi Massimo
Primary Institution: Fondazione G.Monasterio CNR-Regione Toscana, Pisa, Italy
Hypothesis
Can a volumetric IDEAL spiral CSI acquisition method provide spatial information on cardiac metabolism after hyperpolarized [1-13C]pyruvate injection?
Conclusion
The study successfully localized 13C metabolites in the whole pig heart using a 3D IDEAL spiral CSI sequence.
Supporting Evidence
- Pyruvate and its metabolic products lactate and bicarbonate were detected in the heart.
- Metabolic maps were overlaid on anatomical images to show the localization of metabolites.
Takeaway
The researchers used a special imaging technique to see how a substance called pyruvate behaves in a pig's heart, helping us understand heart metabolism better.
Methodology
Three healthy male mini-pigs were injected with hyperpolarized [1-13C]pyruvate, and their heart metabolism was imaged using a 3D IDEAL spiral CSI sequence.
Participant Demographics
Three healthy male mini-pigs, average weight 38±2 kg.
Digital Object Identifier (DOI)
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