Enhanced Antitumoral Activity of Extracts from Cultured Udotea flabellum
Author Information
Author(s): Rosa Moo-Puc, Daniel Robledo, Yolanda Freile-Pelegrin
Primary Institution: Cinvestav
Hypothesis
Does the antiproliferative activity of Udotea flabellum extracts change after cultivation under different light conditions?
Conclusion
Cultivated extracts of Udotea flabellum showed increased antiproliferative activity against cancer cell lines compared to non-cultured extracts.
Supporting Evidence
- After 10 days of cultivation, extracts showed significant increases in antiproliferative activity on HeLa and SiHa cells.
- Extracts from U. flabellum obtained after 10 and 20 days of culture were selected for further analysis.
- Total phenol and lipid content in extracts changed with cultivation time.
Takeaway
This study found that growing a type of seaweed called Udotea flabellum in different light conditions makes it better at fighting cancer cells.
Methodology
Algae were cultured under four light treatments for 30 days, and extracts were tested for antiproliferative activity against four cancer cell lines using SRB assay.
Limitations
The specific compounds responsible for the increased antiproliferative activity remain unidentified.
Statistical Information
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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