Antidiabetic Effects of Elaeocarpus ganitrus in Rats
Author Information
Author(s): Hule Amolkumar K., Shah Abhishek S., Gambhire Manoj N., Juvekar Archana R.
Primary Institution: University Institute of Chemical Technology (UICT), Mumbai University
Hypothesis
The study aims to evaluate the antidiabetic effects of the aqueous extract of Elaeocarpus ganitrus in experimental animals.
Conclusion
The study shows that Elaeocarpus ganitrus seeds have potential antidiabetic effects.
Supporting Evidence
- EGA showed a significant hypoglycemic effect in normoglycemic rats.
- EGA treatment significantly decreased blood glucose levels in STZ-induced diabetic rats in a dose-dependent manner.
- EGA modulated lipid profile changes in STZ-diabetic rats.
- EGA was nontoxic up to a dose of 5 g/kg in acute oral toxicity studies.
Takeaway
This study tested a plant called Elaeocarpus ganitrus to see if it can help lower blood sugar in rats, and it found that it works pretty well.
Methodology
The hypoglycemic activity was evaluated in normoglycemic and STZ-induced diabetic rats using different doses of the extract over a 30-day treatment period.
Limitations
The extract did not restore blood glucose levels to baseline values, indicating it should be used alongside other treatments.
Participant Demographics
Adult male Wistar rats and Swiss albino mice were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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