Diagnostic Value of Autoantibodies in Esophageal Cancer
Author Information
Author(s): Zhou Sihao, Liu Kejun, Yang Yuyu, Yuan Chuan, Liu Yi, Liang Yi, Li Wenhao, Zhang Jingjing, Ye Hongyu, Gong Sheng, Wu Yingmeng, Huang Weizhao
Primary Institution: Zhongshan City People’s Hospital, Zhongshan, Guangdong, China
Hypothesis
This study aimed to investigate the diagnostic value of 7-tumor associated autoantibodies (7-TAAB) and evaluate their relationship with clinical features in esophageal squamous cell carcinoma (ESCC).
Conclusion
The multi-tumor-associated autoantibody combination test has good auxiliary diagnostic value and correlates closely with clinical features of ESCC.
Supporting Evidence
- The serum levels and positivity rates of five antibodies were higher in the ESCC group than in the control group.
- The combined test showed a sensitivity of 49.58% and specificity of 92.98%.
- Age and lymph node stage were independent factors affecting antibody expression.
Takeaway
Doctors can use a test that checks for certain antibodies in the blood to help diagnose a type of throat cancer called esophageal squamous cell carcinoma.
Methodology
Blood samples were collected from patients with ESCC and healthy controls, and the levels of 7-TAAB were measured using enzyme-linked immunosorbent assay (ELISA).
Potential Biases
Potential biases may arise from the selection of participants and the reliance on specific antibody tests.
Limitations
The study's sensitivity for early detection of ESCC is low, and the sample size may not fully represent the population.
Participant Demographics
119 patients with ESCC and 114 healthy controls, with no significant differences in sex, age, or history of tobacco and alcohol use.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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