p53 Genotypes in Oral Cancer Patients from India
Author Information
Author(s): Tandle A T, Sanghvi V, Saranath D
Primary Institution: Tata Memorial Hospital, Tata Memorial Centre, Parel, Mumbai, India
Hypothesis
The study investigates the association of p53 exon 4 codon 72 polymorphism with susceptibility to oral cancer.
Conclusion
The study found no association between p53 genotypes and susceptibility to oral cancer in the Indian population.
Supporting Evidence
- The frequency of p53 genotypes was similar in both oral cancer patients and healthy individuals.
- Allelic loss in the p53 gene was observed in 15% of heterozygous informative oral cancer patients.
Takeaway
The researchers looked at a gene that might affect cancer risk in people with oral cancer, but they found that it didn't seem to make a difference.
Methodology
The study analyzed p53 exon 4 codon 72 polymorphism in blood samples from oral cancer patients and compared it with healthy individuals.
Limitations
The study may be limited by the sample size and the specific population studied.
Participant Demographics
72 oral cancer patients and 153 normal healthy individuals from India.
Statistical Information
Statistical Significance
0.3 <P< 0.5
Digital Object Identifier (DOI)
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