Plasmid-Mediated Quinolone Resistance in Aeromonas spp.
Author Information
Author(s): Vincent Cattoir, Laure Poirel, Camille Aubert, Claude-James Soussy, Patrice Nordmann
Primary Institution: Institut Nationale de la Santé et de la Recherche Médicale Unité 914
Hypothesis
Are plasmid-mediated quinolone resistance determinants present in environmental Aeromonas species?
Conclusion
The study identified plasmid-mediated quinolone resistance determinants in Aeromonas species from water samples in the Seine River, indicating a potential environmental reservoir for these resistance genes.
Supporting Evidence
- QnrS determinants were identified in Aeromonas species from water samples.
- The qnrS2 gene was located on IncU-type plasmids in the isolates.
- Resistance to quinolones and fluoroquinolones was observed in the Aeromonas isolates.
- Plasmid-mediated resistance was confirmed through transfer experiments to E. coli.
Takeaway
Scientists found that some bacteria in the Seine River can resist certain antibiotics because they have special genes that help them survive. This means these bacteria might spread their resistance to other germs.
Methodology
Water samples were collected from six urban sites along the Seine River, and qnr genes were detected using multiplex PCR.
Limitations
The study was limited to specific sampling sites and may not represent the entire river or other environments.
Participant Demographics
Water samples collected from urban sites in Paris, France.
Digital Object Identifier (DOI)
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