Undetectable ultrasensitive PSA after radical prostatectomy for prostate cancer predicts relapse-free survival
2000
PSA Levels After Prostate Surgery and Cancer Recurrence
Sample size: 200
publication
Evidence: high
Author Information
Author(s): Doherty A P, Bower M, Smith G L, Miano R, Mannion E M, Mitchell H
Primary Institution: Department of Urology, Charing Cross Hospital
Hypothesis
Can ultrasensitive PSA assays predict relapse-free survival after radical prostatectomy for prostate cancer?
Conclusion
Undetectable PSA levels after surgery significantly predict a lower chance of cancer relapse.
Supporting Evidence
- Only 3% of patients with undetectable PSA levels relapsed compared to 75% of those with detectable levels.
- The study involved 200 patients who underwent radical retropubic prostatectomy.
Takeaway
Doctors can tell if prostate cancer might come back by checking PSA levels after surgery. If the levels are really low, it's a good sign!
Methodology
The study evaluated PSA levels in patients after radical retropubic prostatectomy to assess the risk of biochemical relapse.
Participant Demographics
Mean age of participants was 61.2 years.
Statistical Information
P-Value
<0.0001
Confidence Interval
95% CI: 51.6–70.6%
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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