Alstonia scholaris Extract Reduces Skin Irritation from Retinoids
Author Information
Author(s): Lee Soo-Jin, Cho Sun-A, An Su-Sun, Na Yong-Joo, Park Nok-Hyun, Kim Han-Sung, Lee Chan-Woo, Kim Han-Kon, Kim Eun-Kyung, Jang Young-Pyo, Kim Jin-Woong
Primary Institution: Amorepacific Co. R&D Center
Hypothesis
Can Alstonia scholaris extract inhibit retinoid-induced skin irritation?
Conclusion
The extract of Alstonia scholaris significantly reduces skin irritation caused by retinoids while enhancing their anti-aging effects.
Supporting Evidence
- The extract significantly suppressed proinflammatory cytokines in vitro.
- Skin irritation scores were significantly lower with the extract compared to control.
- The extract enhanced the ability of retinoids to inhibit matrix metalloproteinase-1 expression.
Takeaway
A plant extract from Alstonia scholaris can help make retinoid treatments for skin less irritating and more effective.
Methodology
The study involved in vitro tests on human keratinocyte cells and a cumulative irritation patch test on human skin.
Limitations
The study was limited to a small sample size and specific demographic.
Participant Demographics
21 healthy adults aged 23 to 36, with 8 males and 13 females.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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