BINDING OF [Au(dien)Cl]Cl2 TO TRIPEPTIDES
Binding of Gold(III) to Tripeptides
publication
Author Information
Author(s): Sabine L. Best, Milos I. Djuran, Peter Sadler
Primary Institution: Birkbeck College, University of London
Hypothesis
The study investigates how Gold(III) binds to tripeptides across different pH levels.
Conclusion
Gold(III) forms strong complexes with tripeptides, with distinct binding characteristics depending on the pH.
Supporting Evidence
- Gold(III) binds strongly to the imidazole ring of glycylglycyl-L-histidine at low pH.
- In the pH range of 3-6.5, three distinct binding species were characterized.
- Binding to the NH2 terminus of triglycine is strong at pH greater than 5.
Takeaway
Gold(III) can stick to certain small protein pieces called tripeptides, and how well it sticks changes with the acidity of the solution.
Methodology
The binding of [Au(III)(diethylenetriamine)Cl]Cl2 to tripeptides was explored over a pH range of 2-10 using 1H NMR.
Want to read the original?
Access the complete publication on the publisher's website