Chromosome Translocation in Acute Promyelocytic Leukaemia
Author Information
Author(s): D. Sheer, T.A. Lister, J. Amess, E. Solomon
Primary Institution: Imperial Cancer Research Fund
Hypothesis
The study investigates the incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
Conclusion
The 15q+;17q- chromosome translocation is found in all seven patients with APL studied.
Supporting Evidence
- The 15q+;17q- chromosome translocation was found in all seven patients with APL.
- Trisomy 10 was found in 50% of cells analyzed in one patient.
- Conditioned media improved the culture of leukaemic cells for chromosome analysis.
Takeaway
The study found that a specific chromosome change happens in almost all patients with a type of blood cancer called acute promyelocytic leukaemia.
Methodology
Cytogenetic analysis was performed on peripheral blood cultures from seven patients diagnosed with APL.
Limitations
The study only included seven patients, which may limit the generalizability of the findings.
Participant Demographics
Patients diagnosed with acute promyelocytic leukaemia (APL) based on FAB criteria.
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