Heme Synthesis Genes in Trypanosomatids
Author Information
Author(s): Alves João M. P., Voegtly Logan, Matveyev Andrey V., Lara Ana M., da Silva Flávia Maia, Serrano Myrna G., Buck Gregory A., Teixeira Marta M. G., Camargo Erney P.
Primary Institution: Virginia Commonwealth University
Hypothesis
The study investigates the genetic basis of heme synthesis in trypanosomatids and their endosymbionts.
Conclusion
The study concludes that the enzymes responsible for heme synthesis are encoded in the genomes of the symbionts and produced in cooperation with the flagellate hosts.
Supporting Evidence
- The enzymes for heme synthesis are encoded in the genomes of the symbionts.
- Extensive gene loss and lateral gene transfer events have shaped the heme synthesis pathways in trypanosomatids.
- Six trypanosomatid species are known to harbor symbionts that assist in heme synthesis.
Takeaway
Some tiny creatures called trypanosomatids can make a special substance called heme with help from tiny bacteria living inside them.
Methodology
The genomes of trypanosomatids and their endosymbionts were sequenced and analyzed phylogenetically to identify heme synthesis genes.
Limitations
The study does not provide complete taxonomic information on the endosymbionts.
Digital Object Identifier (DOI)
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