The NOSE Study (Nasal Ointment for Staphylococcus aureus Eradication): A Randomized Controlled Trial of Monthly Mupirocin in HIV-Infected Individuals
2010
Nasal Ointment for Staphylococcus aureus Eradication in HIV Patients
Sample size: 100
publication
Evidence: high
Author Information
Author(s): Gordon RJ, Chez N, Jia H, Zeller B, Sobieszczyk M, Brennan C
Primary Institution: HELP/PSI, Inc
Hypothesis
Does repeated nasal application of mupirocin ointment decrease the odds of S. aureus nasal colonization in HIV-infected individuals?
Conclusion
Monthly application of nasal mupirocin significantly decreased S. aureus colonization in HIV patients in residential drug rehabilitation.
Supporting Evidence
- Mupirocin reduced the odds of monthly S. aureus nasal colonization by 83% compared with placebo.
- Subjects colonized at study entry had a 91% reduction in subsequent colonization.
- Mupirocin also suppressed S. aureus colonization in subjects not colonized at baseline.
Takeaway
Using a special ointment in the nose can help people with HIV not get a certain germ that can make them sick.
Methodology
A randomized, double-blinded, placebo-controlled study was conducted over an 8-month period.
Participant Demographics
HIV-positive patients at an in-patient drug rehabilitation center.
Statistical Information
P-Value
< 0.0001
Statistical Significance
p<0.0001
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