Impact of Mild Leydig Cell Dysfunction on Fatigue, Sexual Function, and Mood After Cancer Treatment
Author Information
Author(s): Howell S J, Radford J A, Smets E M A, Shalet S M
Primary Institution: Christie Hospital NHS Trust
Hypothesis
Mild testosterone deficiency may account for some of the long-term side-effects of treatment for haematological malignancies.
Conclusion
Mild Leydig cell insufficiency following treatment is not associated with higher levels of fatigue and anxiety but may result in reduced sexual function.
Supporting Evidence
- Fatigue, sexual dysfunction, anxiety, and depression are more common in patients treated with chemotherapy and radiotherapy for haematological malignancies.
- Eighty-seven percent of patients with normal hormone levels were sexually active compared to 69% of those with Leydig cell dysfunction.
- Patients with Leydig cell dysfunction engaged in sexual activity less frequently than those with normal hormone levels.
Takeaway
After cancer treatment, some men may feel more tired and have less interest in sex, especially if they have low testosterone levels.
Methodology
Patients with Leydig cell dysfunction and those with normal hormone levels were assessed for fatigue, mood, and sexual function using questionnaires.
Limitations
The study does not provide a convincing argument for mandatory androgen replacement therapy for all patients.
Participant Demographics
Patients treated for haematological malignancies, with 36 having Leydig cell dysfunction and 30 with normal hormone levels.
Statistical Information
P-Value
0.1
Statistical Significance
p=0.02
Digital Object Identifier (DOI)
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