Chronic Lymphocytic Leukemia Infiltrating in the Brain
Author Information
Author(s): Muacevic Alexander, Adler John R, Webb Lauren M, Kenderian Saad S, Angeli Allison M, Howard Matthew T, Wijdicks Eelco F
Primary Institution: Mayo Clinic, Rochester, USA
Conclusion
The case illustrates a rare neurologic manifestation of chronic lymphocytic leukemia (CLL) that led to poor outcomes despite treatment.
Supporting Evidence
- The patient had severe hyponatremia and stress-induced cardiomyopathy.
- Brain imaging revealed widespread T2 hyperintensities.
- Cerebrospinal fluid analysis showed elevated lymphocytes and malignant CD5+ B cells.
- Brain biopsy confirmed infiltration of CLL cells in the brain parenchyma.
Takeaway
This study is about a 72-year-old man with a rare case of leukemia that spread to his brain, causing serious health issues. Even after treatment, he didn't recover fully.
Methodology
The patient underwent imaging studies, cerebrospinal fluid analysis, and a brain biopsy to confirm the diagnosis and assess treatment response.
Limitations
The study is based on a single case, limiting the generalizability of the findings.
Participant Demographics
The patient was a 72-year-old male with chronic lymphocytic leukemia.
Digital Object Identifier (DOI)
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