Absolute configuration of 3β-acetoxyolean-11,12-aziridin-28,13-β-olide C32H49NO4
2011
Study of a Natural Compound from Garcinia atroviridis
publication
Evidence: moderate
Author Information
Author(s): Tan Wen Nee, Wong Keng Chong, Khairuddean Melati, Hemamalini Madhukar, Fun Hoong-Kun
Primary Institution: Universiti Sains Malaysia
Hypothesis
The study aims to determine the absolute configuration of the compound 3β-acetoxyolean-11,12-aziridin-28,13-β-olide isolated from Garcinia atroviridis.
Conclusion
The absolute configuration of the compound was successfully determined, revealing eleven chiral centers with specific configurations.
Supporting Evidence
- The compound was isolated from the dichloromethane extract of Garcinia atroviridis stem bark.
- Eleven chiral centers were identified in the molecule with specific configurations.
- The study utilized X-ray crystallography to determine the structure.
Takeaway
Researchers looked at a natural compound from a plant and figured out how its atoms are arranged in space.
Methodology
The compound was isolated using Soxhlet extraction and silica gel column chromatography, followed by crystallization.
Digital Object Identifier (DOI)
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