Lemierre's Syndrome and Genetic Polymorphisms: A Case Report
Author Information
Author(s): Constantin Jean-Michel, Mira Jean-Paul, Guerin Renaud, Cayot-Constantin Sophie, Lesens Olivier, Gourdon Florence, Romaszko Jean-Pierre, Linval Philippe, Laurichesse Henri, Bazin Jean-Etienne
Primary Institution: University Hospital of Clermont-Ferrand
Hypothesis
Can genetic polymorphisms influence the symptoms of Lemierre's syndrome?
Conclusion
The innate immune response and prothrombogenic mutations could explain the symptoms of Lemierre's syndrome.
Supporting Evidence
- The patient had functional variations in her TLR 5 gene.
- Two coagulation variations were associated with thrombotic events.
- The patient was diagnosed with septic shock and acute respiratory distress syndrome.
Takeaway
A 17-year-old girl with Lemierre's syndrome had some genetic changes that might have made her more sick. Studying more patients could help us understand this illness better.
Methodology
DNA was assayed for single nucleotide polymorphisms related to pathogen detection and inflammatory response.
Limitations
Only one patient was studied, limiting the generalizability of the findings.
Participant Demographics
17-year-old female with no previous medical history.
Digital Object Identifier (DOI)
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