Targeting Angiogenesis for Controlling Neuroblastoma
Author Information
Author(s): Roy Choudhury Subhasree, Karmakar Surajit, Banik Naren L., Ray Swapan K.
Primary Institution: University of South Carolina School of Medicine
Hypothesis
Prevention of angiogenesis can be a highly significant strategy in the treatment of malignant neuroblastoma.
Conclusion
Inhibition of neovascularization by anti-angiogenic agents could provide a promising therapeutic approach for treatment of neuroblastoma.
Supporting Evidence
- Neuroblastoma is the most common extracranial solid tumor in children.
- Angiogenesis is a major factor in making malignant neuroblastoma.
- Emerging treatments with antiangiogenic molecules can hinder neovascularization.
- Novel therapeutic approaches with angiogenic inhibitors are expected to improve patient survivability.
Takeaway
Neuroblastoma is a type of cancer in children that grows by forming new blood vessels. Stopping these blood vessels from forming can help treat the cancer.
Methodology
This review summarizes current understanding of angiogenesis in malignant neuroblastoma and describes the use of experimental anti-angiogenic agents either alone or in combination therapy.
Limitations
The publication does not provide specific data on clinical trials or patient outcomes.
Digital Object Identifier (DOI)
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