Combining NSAIDs and NF-κB Inhibitors for Ovarian Cancer Treatment
Author Information
Author(s): Zerbini Luiz F., Tamura Rodrigo E., Correa Ricardo G., Czibere Akos, Cordeiro Jason, Bhasin Manoj, Simabuco Fernando M., Wang Yihong, Gu Xuesong, Li Linglin, Sarkar Devanand, Zhou Jin-Rong, Fisher Paul B., Libermann Towia A.
Primary Institution: Beth Israel Deaconess Medical Center and Harvard Medical School
Hypothesis
Targeting NF-κB could enhance NSAID-mediated apoptosis induction in ovarian cancer cells.
Conclusion
Combining NSAIDs with NF-κB inhibitors significantly enhances apoptosis induction in ovarian cancer cells.
Supporting Evidence
- NSAIDs like Sulindac Sulfide and Diclofenac were found to induce apoptosis in ovarian cancer cells.
- The combination of NSAIDs and NF-κB inhibitors resulted in a synergistic effect on apoptosis induction.
- In vivo studies showed that NSAID treatment reduced tumor growth in SCID mice.
Takeaway
This study shows that using certain pain relievers together with specific cancer drugs can help kill ovarian cancer cells better than using either one alone.
Methodology
The study evaluated various NSAIDs for their ability to induce apoptosis in ovarian cancer cells and tested combinations with NF-κB inhibitors.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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