Nutritional Interventions and Placental Phenotype
Author Information
Author(s): Bonnell Victoria, White Marina, Connor Kristin
Primary Institution: Department of Health Sciences, Carleton University, Ottawa, Canada
Hypothesis
Nutritional interventions influence placental phenotype, and these placental changes relate to how successful an intervention is in improving pregnancy outcomes.
Conclusion
Nutritional interventions during pregnancy are associated with altered placental development and function, which likely benefits pregnancy and improves offspring outcomes.
Supporting Evidence
- Micronutrient interventions associated with altered placental function in 48% of studies.
- 82% of lipid-based interventions were linked to changes in placental phenotype.
- Interventions that influenced placental phenotype were more likely to improve maternal and offspring outcomes.
Takeaway
Eating the right foods before and during pregnancy can help the placenta grow and work better, which is good for both the mom and the baby.
Methodology
A systematic review of clinical trials that administered maternal nutritional interventions during pregnancy and reported on placental phenotype.
Potential Biases
Some studies had high or unclear risk of bias due to lack of blinding and unclear compliance data.
Limitations
High variability in types of placental outcomes reported and lack of standardization in data collection.
Participant Demographics
Included pregnant individuals of any age receiving nutritional interventions, with a majority from high-income countries.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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