Treatment of Malignant Ascites in Lung Cancer
Author Information
Author(s): Kimura Hideki, Iizasa Toshihiko, Ishikawa Aki, Yoshino Mitsuru, Shingyouji Masato, Kimura Masaki, Hirata Tetushi, Odaka Akiko, Matsubayasi Keiko
Primary Institution: Chiba Cancer Center, Chiba, Japan
Hypothesis
Can a combination of abdominocentesis, reinfusion of concentrated ascites, and immunotherapy effectively treat malignant ascites in lung cancer patients?
Conclusion
The combination of local administration of immune cells and infusion of concentrated cell-free ascites may be effective for patients with refractory ascites.
Supporting Evidence
- The patient had a drastic decrease in tumor cell count after treatment.
- The plasma protein level was maintained during the treatment despite repeated drainage.
- Cytological examination showed a shift from carcinoma cells to lymphocytes after treatment.
Takeaway
Doctors treated a woman with severe fluid buildup from cancer by draining the fluid, cleaning it, and giving her special immune cells to help fight the cancer.
Methodology
The patient underwent abdominocentesis, reinfusion of concentrated ascites, and intraperitoneal immunotherapy with dendritic cells and activated killer cells.
Limitations
The treatment may be difficult to apply to other patients due to the rarity of abdominal recurrence as malignant ascites.
Participant Demographics
A 55-year-old woman with recurrent lung cancer.
Digital Object Identifier (DOI)
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