Assessing Heart Function in Pulmonary Hypertension
Author Information
Author(s): Shehata Monda L, Basha Tamer A, Harouni Ahmed A, Skrok Jan, Singh Sukhminder, Mathai Stephen, Lima Joao AC, Osman Nael F, Bluemke David A, Hassoun Paul M, Vogel-Claussen Jens
Primary Institution: Johns Hopkins University
Hypothesis
The study aims to evaluate regional longitudinal ventricular deformation in relation to global ventricular dysfunction markers and pulmonary hemodynamics in pulmonary hypertension patients.
Conclusion
In pulmonary hypertension patients, reduced right ventricular strain is linked to increased heart workload and correlates with overall heart dysfunction.
Supporting Evidence
- PH patients showed reduced ELL at all RV levels compared to controls.
- Reduced mean RV ELL correlated with elevated mPAP and pulmonary vascular resistance.
- Reduced LV antero-septal ELL correlated with increased mPAP and reduced RV systolic function.
Takeaway
This study looked at how well the heart works in people with high blood pressure in the lungs, finding that some parts of the heart aren't working as well even if the overall function seems okay.
Methodology
The study used fast-SENC MRI and cine imaging to assess heart function in 35 pulmonary hypertension patients and 13 controls.
Limitations
The study may have limitations related to the small sample size and the specific population studied.
Participant Demographics
35 pulmonary hypertension patients and 13 age and gender matched controls.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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