ReplicationDomain: A Tool for Visualizing Genome-Wide Replication Timing Data
Author Information
Author(s): Weddington Nodin, Stuy Alexander, Hiratani Ichiro, Ryba Tyrone, Yokochi Tomoki, Gilbert David M
Primary Institution: Florida State University
Hypothesis
Replication timing is a unique epigenetic property of chromatin regulated at the level of megabase-sized domains.
Conclusion
ReplicationDomain is a powerful tool that facilitates the comparative visualization of replication timing in various cell types and is faster and more convenient than existing browsers.
Supporting Evidence
- ReplicationDomain allows users to graphically display and download genome-wide data sets.
- The tool provides a user registration system for data upload and sharing.
- It is designed for rapid viewing of multi-megabase segments of chromosomes.
Takeaway
ReplicationDomain helps scientists see how DNA is copied in different types of cells, making it easier to understand important genetic information.
Methodology
Developed as a web-based database for analysis of genome-wide replication timing maps from various cell lines and species.
Limitations
Currently accommodates only mouse data and is not as comprehensive as other databases.
Digital Object Identifier (DOI)
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