The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
2011
The ADAMs Family of Proteases: New Biomarkers and Therapeutic Targets for Cancer
publication
Evidence: moderate
Author Information
Author(s): Duffy Michael J, Mullooly Maeve, O'Donovan Norma, Sukor Sumainizah, Crown John, Pierce Aisling, McGowan Patricia M
Primary Institution: St. Vincent's University Hospital, Dublin, Ireland
Hypothesis
Are ADAMs potential biomarkers and therapeutic targets for cancer?
Conclusion
ADAMs are implicated in cancer progression and may serve as biomarkers and therapeutic targets.
Supporting Evidence
- ADAMs are involved in the activation of growth factors that promote cancer.
- Certain ADAMs have been shown to enhance cancer cell proliferation and invasion.
- ADAM12 levels in urine can indicate breast cancer presence.
- High levels of ADAM17 protein correlate with shorter survival in breast cancer patients.
Takeaway
ADAMs are proteins that help cancer grow, and scientists think they can be used to find and treat cancer better.
Methodology
The article reviews existing literature on the role of ADAMs in cancer.
Limitations
The findings require confirmation in larger studies.
Digital Object Identifier (DOI)
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