Seattle Structural Genomics Center for Infectious Disease Overview
Author Information
Author(s): Stacy Robin, Darren W. Begley, Isabelle Phan, Bart L. Staker, Wesley C. Van Voorhis, Gabriele Varani, Garry W. Buchko, Lance J. Stewart, Peter J. Myler
Primary Institution: Seattle Structural Genomics Center for Infectious Disease
Conclusion
The SSGCID aims to provide structural data for drug targets from infectious diseases, significantly contributing to drug discovery efforts.
Supporting Evidence
- The SSGCID has approved 7564 targets for structure determination.
- The consortium collaborates with the scientific community to prioritize target nominations.
- SSGCID has submitted over 300 structures to the Protein Data Bank.
Takeaway
The SSGCID helps scientists understand how germs work by figuring out the shapes of important proteins, which can help make new medicines.
Methodology
The SSGCID uses a high-throughput pipeline for protein structure determination, including target selection, cloning, expression testing, and crystallization.
Limitations
The success rate for structure determination varies significantly between different genera of pathogens.
Participant Demographics
The SSGCID involves researchers from multiple institutions in the Pacific Northwest of the United States.
Digital Object Identifier (DOI)
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