New Diterpenoids from Teucrium quadrifarium and Their Effects on Cell Death
Author Information
Author(s): Wang Huan, Liu Han-Fei, Yang Xiao-Qiao, Liao Yu-Qiong, Pan Fen-Cong, Li Jin-Yu, Pan Wei-Dong
Primary Institution: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University
Hypothesis
The study investigates the anti-ferroptosis effects of newly isolated neo-clerodane diterpenoids from Teucrium quadrifarium.
Conclusion
The study found that new compound 1 significantly inhibits ferroptosis in HT22 cells induced by RSL3.
Supporting Evidence
- Four new neo-clerodane diterpenoids were isolated from Teucrium quadrifarium.
- Compounds 1 and 12 showed significant inhibitory effects against ferroptosis in HT22 cells.
- The EC50 values for compounds 1 and 12 were 11.8 μM and 4.52 μM, respectively.
Takeaway
Scientists found new plant compounds that can help protect brain cells from a type of cell death called ferroptosis.
Methodology
The compounds were isolated from Teucrium quadrifarium and their effects on ferroptosis were tested in HT22 cells.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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