NetB: A Toxin Linked to Necrotic Enteritis in Chickens
Author Information
Author(s): Keyburn Anthony L., Bannam Trudi L., Moore Robert J., Rood Julian I.
Primary Institution: CSIRO Livestock Industries, Australian Animal Health Laboratory
Hypothesis
Is NetB a key virulence factor in Clostridium perfringens strains that cause avian necrotic enteritis?
Conclusion
NetB is essential for the pathogenesis of necrotic enteritis in chickens and is produced by most strains isolated from necrotic lesions.
Supporting Evidence
- NetB is produced by a subset of avian C. perfringens type A strains.
- NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis.
- Virulence testing showed that necrotic enteritis in chickens depends on the ability to produce functional NetB toxin.
- NetB has been identified in 60 to 90% of strains isolated from birds with necrotic enteritis.
Takeaway
NetB is a toxin made by certain bacteria that can make chickens very sick. Understanding it can help us create better vaccines to protect the birds.
Methodology
The review examines the biology, distribution, regulation, and potential vaccine applications of the NetB toxin.
Limitations
The study does not address the exact structure of the NetB toxin or its receptor.
Digital Object Identifier (DOI)
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