Uric Acid Correlates with Serum Levels of Mineral Bone Metabolism and Inflammation Biomarkers in Patients with Stage 3a–5 Chronic Kidney Disease

2024

Uric Acid and Bone Health in Chronic Kidney Disease

Sample size: 146 publication 10 minutes Evidence: moderate

Author Information

Author(s): Francisco Mendoza Carrera, Gloria Elizabeth Vázquez Rivera, Caridad A. Leal Cortés, Lourdes del Carmen Rizo De la Torre, Renato Parra Michel, Rosalba Orozco Sandoval, Mariana Pérez Coria

Primary Institution: División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico

Hypothesis

The study aims to evaluate the relationship between uric acid levels and mineral bone metabolism and inflammation biomarkers in patients with chronic kidney disease stages 3a to 5.

Conclusion

The study supports the relationship between uric acid and levels of mineral bone metabolism and inflammation biomarkers in patients with chronic kidney disease.

Supporting Evidence

Patients with hyperuricemia had significantly higher values of FGF23 and TNF-α compared to those without hyperuricemia.
The eGFR was significantly and negatively correlated with all markers.
Uric acid was significantly correlated with phosphate, iPTH, FGF23, and TNF-α.

Takeaway

This study found that high levels of uric acid in people with kidney disease are linked to problems with bone health and inflammation.

Methodology

A cross-sectional study measuring serum concentrations of uric acid, mineral bone metabolism, and inflammation biomarkers in patients with chronic kidney disease.