Clinical Characteristics and Risk Factors of Hepatitis E in Central China
Author Information
Author(s): Zhang Shujun, Wang Jingjing, Yuan Quan, Ge Shengxiang, Zhang Jun, Xia Ningshao, Tian Deying
Primary Institution: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hypothesis
What are the clinical features and risk factors associated with sporadic Hepatitis E in central China?
Conclusion
Total bilirubin, blood urea nitrogen, and international normalized ratio are major risk factors for mortality in Hepatitis E patients, especially those with liver cirrhosis.
Supporting Evidence
- The overall mortality rate among the patients was 10%.
- Patients with liver cirrhosis had a mortality rate of 25%.
- Jaundice, fatigue, and anorexia were the most common symptoms.
Takeaway
This study found that Hepatitis E can be very serious, especially for people with liver problems, and certain blood tests can help predict who might be at risk of dying from it.
Methodology
The study included 210 hospitalized patients diagnosed with Hepatitis E, with various biochemical tests and follow-ups conducted over six months.
Potential Biases
Potential bias due to the selection of critically ill patients from a referral hospital.
Limitations
The study was limited to a single hospital and may not represent the broader population.
Participant Demographics
85.2% male, ages ranged from 17 to 92 years, with a mean age of 48.7 years.
Statistical Information
P-Value
0.002
Confidence Interval
95% CI: 6.63%-14.80%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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