Understanding Spiral Waves in Cardiac Tissue Recovery
Author Information
Author(s): Biktashev Vadim N., Biktasheva Irina V., Sarvazyan Narine A.
Primary Institution: University of Liverpool
Hypothesis
What determines the components of the drift velocity of spiral waves in recovering cardiac tissue?
Conclusion
The study shows that the dynamics of spiral waves in recovering cardiac tissue are influenced by gradients of excitability and coupling, which can lead to arrhythmogenic conditions.
Supporting Evidence
- Spiral waves can be attracted to areas of lower excitability in cardiac tissue.
- The dynamics of spiral waves are influenced by the gradient of excitability and coupling strength.
- Scroll waves can persist in better-coupled tissue if filament tension is negative.
Takeaway
This study looks at how waves of electrical activity in the heart can change when the heart is recovering from a lack of blood flow, which can lead to dangerous heart rhythms.
Methodology
The study used mathematical modeling and numerical simulations to analyze the behavior of spiral and scroll waves in cardiac tissue under conditions mimicking recovery from ischemia.
Limitations
The model simplifies complex biological processes and may not fully capture all factors influencing cardiac behavior in real-life scenarios.
Digital Object Identifier (DOI)
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