SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis
2006
SSeCKS Reduces Cancer Growth by Modulating Gene Expression
publication
Evidence: moderate
Author Information
Author(s): Liu Yongzhong, Gao Lingqiu, Gelman Irwin H
Primary Institution: National Institutes of Health, Bethesda, MD, USA; Roswell Park Cancer Institute, Buffalo, NY, USA
Hypothesis
Can SSeCKS re-expression inhibit oncogenic growth induced by v-Src?
Conclusion
SSeCKS can suppress Src-induced oncogenesis by modulating gene expression downstream of Src kinase activity.
Supporting Evidence
- SSeCKS re-expression inhibited v-Src-induced oncogenic growth.
- SSeCKS downregulated several critical genes associated with cancer growth.
- SSeCKS induced expression of cell cycle regulatory genes.
Takeaway
SSeCKS is a protein that helps stop cancer cells from growing by changing how certain genes work.
Methodology
The study used cDNA microarrays and semi-quantitative RT-PCR to analyze gene expression changes in NIH3T3 cells with regulated SSeCKS expression and active v-Src.
Digital Object Identifier (DOI)
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