Homocysteine and Familial Longevity: The Leiden Longevity Study
Author Information
Author(s): Wijsman Carolien A., van Heemst Diana, Rozing Maarten P., Slagboom P. Eline, Beekman Marian, de Craen Anton J. M., Maier Andrea B., Westendorp Rudi G. J., Blom Henk J., Mooijaart Simon P.
Primary Institution: Leiden University Medical Center, Leiden, The Netherlands
Hypothesis
Is homocysteine lower in individuals that are genetically enriched for longevity?
Conclusion
Homocysteine metabolism is not likely to predict familial longevity.
Supporting Evidence
- Homocysteine concentrations were related to age, creatinine, folate, vitamin B levels, and medical history of hypertension and stroke.
- Levels of homocysteine did not differ between offspring enriched for longevity and their partners.
- No differences in the age-related rise in homocysteine levels were found between groups.
Takeaway
The study looked at whether people from families known for long life have lower levels of a substance called homocysteine, but found no difference compared to their partners.
Methodology
Measured total homocysteine concentrations in 1907 subjects, including 1309 offspring of nonagenarian siblings and 598 partners as controls.
Limitations
Did not measure other metabolites of the methionine cycle, which may also relate to longevity.
Participant Demographics
Participants included 1309 offspring of long-lived siblings and 598 partners, with no selection criteria on health or demographic characteristics.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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