7-Chloro-5-cyclopropyl-9-methyl-5H-4,5,6,10-tetraazadibenzo[a,d]cyclohepten-11(10H)-one
2011
Study of a Chloro Derivative of Nevirapine
publication
Evidence: moderate
Author Information
Author(s): Naveen S., Thimmegowda N. R., Manjunath H. R., Sridhar M. A., Prasad J. Shashidhara, Rangappa K. S.
Primary Institution: Sri Bhagawan Mahaveer Jain College of Engineering, Jain University, Bangalore
Hypothesis
The study investigates the structure and properties of a chloro derivative of the anti-HIV drug Nevirapine.
Conclusion
The synthesized compound adopts a butterfly shape and forms polymeric chains through hydrogen bonding.
Supporting Evidence
- The diazepine ring in the compound is in a twisted boat conformation.
- The molecule exhibits intermolecular hydrogen bonds of the N—H···N and C—H···O type.
- The compound was synthesized as a basic scaffold for further derivatives.
Takeaway
Researchers made a new version of a medicine that helps fight HIV and found that its shape is important for how it works.
Methodology
The compound was synthesized and its structure was confirmed using X-ray diffraction.
Digital Object Identifier (DOI)
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