Long-Term Study of Brain Changes in First-Episode Psychosis
Author Information
Author(s): Berthet Pierre, Haatveit Beathe C, Kjelkenes Rikka, Worker Amanda, Kia Seyed Mostafa, Wolfers Thomas, Rutherford Saige, Alnaes Dag, Dinga Richard, Pedersen Mads L, Dahl Andreas, Fernandez-Cabello Sara, Dazzan Paola, Agartz Ingrid, Nesvåg Ragnar, Ueland Torill, Andreassen Ole A, Simonsen Carmen, Westlye Lars T, Melle Ingrid, Marquand Andre
Primary Institution: University of Oslo
Hypothesis
We predicted that individual differences in cortical deviations would be coupled to clinical outcome over time.
Conclusion
The study found that cortical differences in patients with first-episode psychosis attenuated over time alongside a reduction in symptoms.
Supporting Evidence
- Patients showed significant reductions in PANSS scores over time.
- Cortical deviations in patients were more negative at baseline but improved over the follow-up period.
- Normative models provided a framework for comparing brain structure across different scanners.
Takeaway
This study looked at how the brains of people with first-episode psychosis change over 10 years, finding that their brain differences and symptoms got better over time.
Methodology
The study used structural MRI scans and normative models to assess cortical thickness in patients and healthy controls over 10 years.
Potential Biases
Potential biases in recruitment and retention of participants may affect the findings.
Limitations
The sample size at the third follow-up was moderate, which could bias findings, and the study could not directly test the effects of different antipsychotic medications.
Participant Demographics
The study included 79 patients with first-episode psychosis and 218 healthy controls, with a mean age of 27.8 years for patients at baseline.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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