The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium
2011
Role of p75 Neurotrophin Receptor in Choroid Plexus
publication
Evidence: moderate
Author Information
Author(s): Carlos Spuch, Eva Carro
Primary Institution: Neuroscience Group, Research Institute Hospital 12 de Octubre, Madrid, Spain
Hypothesis
p75NTR may affect survival pathways in the choroid plexus and undergo regulated proteolysis.
Conclusion
The study reveals that p75NTR is present in choroid plexus epithelial cells and plays a role in cell death mechanisms and Aβ transport.
Supporting Evidence
- p75NTR was detected in choroid plexus epithelial cells.
- p75NTR is involved in Aβ-induced cell death.
- Blocking p75NTR activity prevents Aβ-induced cell death.
Takeaway
The p75 neurotrophin receptor is found in brain cells that help produce cerebrospinal fluid, and it can affect how these cells respond to damage.
Methodology
The study used immunofluorescence, Western blot analysis, and in vitro double-chamber systems to investigate p75NTR expression and function.
Digital Object Identifier (DOI)
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