Change in Oestrogen Receptor Status of Breast Cancer with Age
Author Information
Author(s): D.J. Gaskell, K. Sangster, A.L. Tesdale, D. Carson, R.A. Hawkins
Primary Institution: University Department of Surgery, The Royal Infirmary, Edinburgh
Hypothesis
Does the oestrogen receptor status of breast cancer change with age?
Conclusion
The study concludes that older patients tend to have a higher proportion of oestrogen receptor-positive tumours, which may affect their response to endocrine therapy.
Supporting Evidence
- There was a strong correlation between the two assays used to measure oestrogen receptor levels.
- Older patients had a higher proportion of oestrogen receptor-positive tumours.
- The intensity of staining for oestrogen receptors increased with age.
Takeaway
As people get older, their breast cancer is more likely to have oestrogen receptors, which can influence how well treatments work.
Methodology
The study used immunocytochemical assays and radioligand-binding assays to measure oestrogen receptor status in breast cancer patients.
Limitations
The study may not account for all factors influencing oestrogen receptor status and response to therapy.
Participant Demographics
Mean age of participants was 67 years, with a range from 35 to 86 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
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