EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells
2001
Green Tea Compound EGCG Helps Fight Colon Cancer
Sample size: 30
publication
Evidence: moderate
Author Information
Author(s): Jung Y D, Kim M S, Shin B A, Chay K O, Ahn B W, Liu W, Bucana C D, Gallick G E, Ellis L M
Primary Institution: Chonnam University Research Institute of Medical Sciences, Chonnam University Medical School
Hypothesis
Does EGCG inhibit tumor growth by affecting VEGF induction in colon cancer cells?
Conclusion
EGCG significantly inhibits tumor growth and angiogenesis in colon cancer cells.
Supporting Evidence
- EGCG inhibited Erk-1 and Erk-2 activation in a dose-dependent manner.
- EGCG reduced VEGF expression and promoter activity.
- EGCG treatment led to a 58% inhibition of tumor growth.
- Microvessel density decreased by 30% with EGCG treatment.
- Tumor cell proliferation was reduced by 27% with EGCG.
- EGCG increased tumor cell apoptosis by 1.9-fold.
- Endothelial cell apoptosis increased by 3-fold with EGCG treatment.
Takeaway
A compound in green tea called EGCG can help stop cancer cells from growing by blocking a substance that helps tumors get blood.
Methodology
In vitro studies on human colon cancer cells and in vivo studies on mice were conducted to assess the effects of EGCG.
Participant Demographics
Athymic BALB/c nude mice were used in the in vivo studies.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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