Matrilysin's Role in Early Invasive Colorectal Cancer
Author Information
Author(s): Masaki T, Matsuoka H, Sugiyama M, Abe N, Goto A, Sakamoto A, Atomi Y
Primary Institution: Kyorin University
Hypothesis
This study aims to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas.
Conclusion
Matrilysin expression and tumour budding are important indicators for identifying high-risk patients with early invasive colorectal carcinomas.
Supporting Evidence
- Matrilysin expression was significantly associated with distant metastasis.
- Both tumour budding and matrilysin expression were significantly associated with adverse outcomes.
- Histological differentiation, vessel invasion, and depth of invasion were not significantly associated with distant metastasis or adverse outcomes.
- Multivariate analysis confirmed that tumour budding and matrilysin expression were independently associated with adverse outcomes.
Takeaway
This study found that a protein called matrilysin can help doctors figure out which early colorectal cancers are more likely to spread and cause problems.
Methodology
The study examined 38 early invasive colorectal carcinomas and evaluated matrilysin protein levels using immunohistochemistry.
Statistical Information
P-Value
P= 0.0339, 0.0005, 0.0341, 0.0488
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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