Study on Genetic Variants and Heart Disease Risk
Author Information
Author(s): Abbas Dehghan, Mandy van Hoek, Eric JG Sijbrands, Ben A Oostra, Albert Hofman, Cornelia M van Duijn, Jacqueline CM Witteman
Primary Institution: Erasmus Medical Center, Rotterdam, the Netherlands
Hypothesis
Are the SNPs rs10757278 and rs10757274 associated with the risk of coronary heart disease and myocardial infarction in an elderly population?
Conclusion
The study found no significant association between the SNPs and the risks of coronary heart disease and myocardial infarction.
Supporting Evidence
- The study included 7983 participants aged 55 years and older.
- No significant association was found between the SNPs and the risks of coronary heart disease or myocardial infarction.
- The study had sufficient power to detect effect sizes as shown in published studies.
Takeaway
The researchers looked at two genetic changes to see if they could cause heart problems in older people, but they found that they didn't.
Methodology
The study used a population-based, prospective cohort design with Cox proportional hazards analyses to assess associations.
Limitations
The study may be underpowered to detect the effect of age on the association and participants were not fully followed.
Participant Demographics
Participants were elderly individuals aged 55 years and older from the Rotterdam Study.
Statistical Information
Confidence Interval
95% confidence interval for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) respectively.
Digital Object Identifier (DOI)
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