The role of centrosomal Nlp in the control of mitotic progression and tumourigenesis
2011
The role of centrosomal Nlp in mitotic progression and tumorigenesis
publication
Evidence: moderate
Author Information
Author(s): Li J, Zhan Q
Primary Institution: State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China
Hypothesis
The human centrosomal ninein-like protein (Nlp) is essential for proper execution of various mitotic events and is linked to tumorigenesis.
Conclusion
Nlp is involved in tumorigenesis, as its overexpression and gene amplification are frequently observed in human cancers.
Supporting Evidence
- Nlp is linked to human cancer through its role in mitotic events.
- Overexpression of Nlp can induce anchorage-independent growth.
- Nlp transgenic mice develop spontaneous tumors.
- Nlp is frequently overexpressed in various human cancers.
- Nlp's expression is elevated due to gene amplification in breast and lung cancers.
Takeaway
Nlp helps cells divide properly, and when it doesn't work right, it can lead to cancer.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website