KL-VS Variant of KLOTHO and Type 2 Diabetes
Author Information
Author(s): Rachel M Freathy, Michael N Weedon, David Melzer, Beverley Shields, Graham A Hitman, Mark Walker, Mark I McCarthy, Andrew T Hattersley, Timothy M Frayling
Primary Institution: Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Hypothesis
Is the KL-VS variant associated with type 2 diabetes in a UK Caucasian population?
Conclusion
The study found no evidence that the KL-VS variant is a risk factor for type 2 diabetes.
Supporting Evidence
- The study included 1793 cases and 1619 controls.
- No significant associations were found between the KL-VS variant and type 2 diabetes.
- The study was powered to detect odds ratios of 1.2.
- Analysis of quantitative traits showed no significant associations with fasting insulin or glucose.
Takeaway
Researchers wanted to see if a specific gene variant was linked to diabetes, but they found out it wasn't.
Methodology
The study involved genotyping cases and controls for the KL-VS variant and comparing allele frequencies.
Limitations
The study may not capture all common variation across KL and cannot rule out the effects of rare variants.
Participant Demographics
UK Caucasians, including 1793 cases with type 2 diabetes and 1619 controls.
Statistical Information
P-Value
0.50
Confidence Interval
0.84–1.09
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website