Immunological and Viral Determinants of Dengue Severity in Hospitalized Adults in Ha Noi, Viet Nam
Author Information
Author(s): Fox Annette, Hoa Le Nguyen Minh, Simmons Cameron P., Wolbers Marcel, Wertheim Heiman F. L., Khuong Pham Thi, Ninh Tran Thi Hai, Lien Trinh Thi Minh, Lien Nguyen Thi, Trung Nguyen Vu, Hien Nguyen Duc, Farrar Jeremy, Horby Peter, Taylor Walter R., Van Kinh Nguyen
Primary Institution: Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hanoi, Socialist Republic of Vietnam
Hypothesis
The study examines the interactions between dengue serotype, primary and secondary infection, viremia, and dengue severity in hospitalized adults.
Conclusion
Dengue is a significant public health issue in Ha Noi, with DENV-1 and DENV-2 being the prevalent serotypes, and secondary infections may lead to more severe outcomes.
Supporting Evidence
- 158 patients were enrolled in the study, with 130 confirmed cases of dengue.
- Secondary infections were more common in DENV-2 infections (79%) compared to DENV-1 (36%).
- The study found no association between plasma viral RNA concentration and clinical severity.
Takeaway
Dengue can make people very sick, and some types of the virus can make it worse, especially if someone has had it before.
Methodology
This cross-sectional study involved 158 hospitalized patients diagnosed with dengue, using RT-PCR and serology to confirm infections and categorize them as primary or secondary.
Potential Biases
Potential bias due to late patient admissions affecting viral RNA detection.
Limitations
The study was limited to one hospital in Hanoi and did not include children due to low admission rates.
Participant Demographics
Patients were predominantly adults with a median age of 23.5 years, and 53% were male.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 0.80 – 4.85
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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