Varicella and Herpes Zoster in Madrid: 1997–2004
Author Information
Author(s): Pérez-Farinós Napoleón, Ordobás María, García-Fernández Cristina, García-Comas Luis, Cañellas Soledad, Rodero Inmaculada, Gutiérrez-Rodríguez Ángeles, García-Gutiérrez Juan, Ramírez Rosa
Primary Institution: Department of Epidemiology, Madrid Public Health Institute
Hypothesis
What is the status and time trend for varicella and herpes zoster in the Madrid Autonomous Region prior to the introduction of the vaccine?
Conclusion
In the absence of vaccination, varicella incidence remained stable, while herpes zoster incidence showed a rising trend.
Supporting Evidence
- A total of 9856 cases of varicella and 1798 cases of herpes zoster were reported.
- Standardised annual varicella incidence rates ranged from 742.5 to 1239.6 cases per 100,000 person-years.
- Most varicella cases affected children, while herpes zoster cases were more frequent among older adults.
- The study found no significant trend in varicella incidence over the years.
- Herpes zoster incidence showed a rising trend, particularly among older age groups.
Takeaway
This study looked at chickenpox and shingles cases in Madrid over several years, finding that chickenpox rates didn't change much, but shingles cases increased.
Methodology
Data was collected from individual varicella and herpes zoster case records by the Madrid Autonomous Region Sentinel General Practitioner Network from 1997 to 2004.
Potential Biases
The reliance on voluntary reporting from general practitioners may introduce reporting bias.
Limitations
The study may not capture all complications as it relies on a representative sample covering approximately 2% of the population.
Participant Demographics
The population attended by the physicians is representative of the Madrid Autonomous Region in terms of age and gender.
Statistical Information
P-Value
0.138 for varicella; 0.026 for herpes zoster
Confidence Interval
95% CI: 687.2 – 797.7 for varicella; 95% CI: 217.9 – 282.0 for herpes zoster
Statistical Significance
p = 0.138 for varicella; p = 0.026 for herpes zoster
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website