Blood Biomarkers and Cognitive Concerns in Alzheimer's Disease
Author Information
Author(s): De La Garza Ángel García, Wang Cuiling, Mogle Jacqueline, Derby Carol, Lipton Richard, Rabin Laura, Katz Mindy
Primary Institution: Albert Einstein College of Medicine
Hypothesis
The study investigates the association between blood-based biomarkers of Alzheimer's Disease and subjective cognitive concerns assessed via smartphone.
Conclusion
The study found that higher levels of pTau181 in blood are associated with increased self-reported cognitive lapses.
Supporting Evidence
- Participants reported an average of 1.53 cognitive lapses daily.
- Every 1 standard deviation increase in pTau181 was linked to 0.21 more memory lapses.
- Every 1 standard deviation increase in pTau181 was linked to 0.11 more executive functioning lapses.
Takeaway
The more pTau181 in your blood, the more you might feel like you're forgetting things.
Methodology
Participants reported daily cognitive lapses over 14 days, and blood biomarkers were analyzed using linear regression.
Participant Demographics
Mean age 77.50, 66.8% Female, 47.6% Non-Hispanic-White, 40.2% Non-Hispanic-Black, 12.1% Hispanic.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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