Tumourigenesis associated with the p53 tumour suppressor gene
1993
The Role of the p53 Tumor Suppressor Gene in Cancer
publication
Evidence: high
Author Information
Author(s): F. Chang, S. Syrjanen, A. Tervahauta, K. Syrjanen
Primary Institution: University of Kuopio
Hypothesis
Loss of normal p53 function is associated with cell transformation and the development of neoplasms.
Conclusion
Inactivation of the p53 tumor suppressor gene is a common step in the development of various human cancers.
Supporting Evidence
- More than 50% of human malignancies analyzed contain an altered p53 gene.
- Mutations in the p53 gene are among the most frequent genetic changes detected in human cancers.
- Loss of normal p53 function increases susceptibility to tumor formation in mice.
Takeaway
The p53 gene helps control cell growth, and when it doesn't work right, it can lead to cancer.
Limitations
The incidence of p53 mutations varies greatly between tumor types and geographical locations.
Want to read the original?
Access the complete publication on the publisher's website