Maspin Expression in Triple-Negative Breast Cancer
Author Information
Author(s): Umekita Yoshihisa, Ohi Yasuyo, Souda Masakazu, Rai Yoshiaki, Sagara Yoshiaki, Sagara Yasuaki, Tamada Shugo, Tanimoto Akihide
Primary Institution: Kagoshima University Graduate School of Medical and Dental Sciences
Hypothesis
Maspin expression may be frequent and correlate with basal rather than myoepithelial markers in TN breast cancer.
Conclusion
Maspin is frequently expressed in triple-negative breast cancer and correlates strongly with basal markers.
Supporting Evidence
- The positive rate for maspin was 85.9%.
- Maspin expression significantly correlated with younger age and higher histological grade.
- Maspin positivity was associated with CK5/6 and CK14 positivity.
Takeaway
Maspin is a protein that is often found in a type of breast cancer called triple-negative breast cancer, and it seems to be linked to other important markers that help understand the cancer better.
Methodology
Immunohistochemical analysis of paraffin-embedded tissue samples from 135 TN invasive ductal carcinoma patients.
Limitations
The study focused only on invasive ductal carcinoma and did not include other breast cancer types.
Participant Demographics
Median age was 56.6 years, with a range from 27 to 91 years.
Statistical Information
P-Value
P = 0.0015, P = 0.0013, P < 0.0001, P = 0.0034, P = 0.013
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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