Blocking VEGF to Treat Kidney Cancer
Author Information
Author(s): Shi W, Siemann D W
Primary Institution: University of Florida
Hypothesis
Can antisense oligonucleotides targeting vascular endothelial growth factor (VEGF) inhibit the growth and angiogenesis of renal cell carcinoma?
Conclusion
The study found that antisense oligonucleotides targeting VEGF significantly impaired the growth and angiogenic potential of renal cell carcinoma in a pre-clinical model.
Supporting Evidence
- Antisense treatment reduced VEGF levels in Caki-1 cells to about 35% of control.
- Caki-1 cells treated with antisense oligonucleotides showed significantly impaired angiogenic potential in vivo.
- Systemic administration of antisense oligonucleotides led to significant delays in tumor growth.
Takeaway
This study shows that a special treatment can help stop kidney cancer from growing by blocking a substance that helps tumors grow new blood vessels.
Methodology
The study used in vitro and in vivo experiments with renal cell carcinoma cells and nude mice to evaluate the effects of VEGF antisense phosphorothioate oligodeoxynucleotides.
Participant Demographics
Female nude mice, age 6–8 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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