Prognostic Factors for Lymph Node Metastasis in Skin Cancer
Author Information
Author(s): Vinicius de Lima Vazquez, Teoclito Sachetto, Natalia Martins Perpetuo, Andre Lopes Carvalho
Primary Institution: Hospital de Cancer de Barretos
Hypothesis
What are the risk factors for lymph node metastasis in advanced squamous cell carcinoma of the skin?
Conclusion
Local advanced tumors are at risk of lymph node metastasis, particularly those with previous lesions, and T4 tumors have a worse prognosis.
Supporting Evidence
- Fifteen patients had previous skin lesions.
- T3 tumors had better survival compared to T4 tumors.
- Eleven N0 patients developed lymph node metastasis during follow-up.
Takeaway
This study looked at patients with advanced skin cancer and found that those with previous skin problems are more likely to have cancer spread to their lymph nodes.
Methodology
Retrospective review of clinical variables in 57 patients with locally advanced SCC.
Potential Biases
Referral bias to a tertiary cancer center may affect the results.
Limitations
The study is retrospective with a relatively small sample size and heterogeneous treatment options.
Participant Demographics
34 men and 23 women, mean age 61.9 years, predominantly Caucasian and from urban areas.
Statistical Information
P-Value
0.047
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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